Beschreibung
Provides a unique overview of efficient synthetic routes to one of the most important compound classes in organic and pharmaceutical chemistry! Amines are among the most important compounds in organic chemistry due to their wide occurrence in natural products, drugs, crop protection compounds, and advanced materials. For example, the majority of drugs are amines or contain functional groups derived from amines. Powerful and efficient methods for the introduction of the amino group are therefore of great importance to synthetic chemists in academia and industry. Methodologies in Amine Synthesis ? Challenges and Applications presents powerful and state-of-the-art methods for the efficient preparation of amines. It summarizes recent advances in the electrophilic amination reaction, hydroamination, C?H amination as well as newly developed photocatalytic approaches. It further describes organocatalytic and enzymatic routes to the generation of amines under mild and environmentally friendly conditions. In addition, it highlights the relevance of the amino function in bioactive molecules, drugs, and in the engineering of smart materials. Finally, the application of palladium-catalyzed aromatic amination in industrial context is critically discussed. * Only uptodate and comprehensive book on the preparation of amines ? one of the most frequently occurring compound classes found in natural products, bioactive molecules, and advanced materials. * Presents efficient and useful synthetic methods, highlights opportunities/ challenges as well as applications in pharmaceutical chemistry and materials science. * Chapters are compiled by well-known experts in the field. One of them edited the previous books ?Modern Amination Methods? (2001) and ?Amino Group Chemistry? (2007). The book Methodologies in Amine Synthesis ? Challenges and Applications is a musthave for chemists in academia and industry working in the field of organic synthesis and catalysis, natural product chemistry, drug synthesis and pharmaceutical chemistry, as well as materials science.
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Hersteller:
Wiley-VCH GmbH
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Autorenportrait
Alfredo Ricci, after his retirement as Professor, is currently visiting scientist at the Department of Industrial Chemistry "Toso Montanari" at Bologna University, Italy. He has authored more than 300 scientific publications and received several awards, including the "French-Italian Prize for Organic Synthesis", the Merck-ADP Grants for Training of Younger Scientists, and the nomination as Fellow of the Japan Society for Promotion of Science (JSPS). Luca Bernardi is Associate Professor at the Department of Industrial Chemistry "Toso Montanari" at Bologna University, Italy. He is co-author of about 80 articles, two patents and four book chapters. He received the "Thieme Journal Prize" in 2009 and the Ciamician Medal of the Organic Chemistry Division in 2010. His research is mainly directed at the development of new catalytic enantioselective reactions.
Leseprobe
Leseprobe