InhaltsangabeSection I Physiology and Pathophysiology of Sleep.- 1 The benzodiazepine receptor in human brain.- 2 Cerebral circulation and metabolism in sleep.- 3 ?- and ?-adrenergic mechanisms in the control of sleep stages.- 4 Brain catecholaminergic activity in relation to sleep.- 5 Melatonin and sleep in man: a preliminary report.- Discussion I.- Section II Treatment of Sleep Disorders 1. Parameters of Efficacy.- 6 Clinical pharmacokinetic and biopharmaceutical aspects of hypnotic drug therapy.- 7 Clinical and psychometric effects of flunitrazepam observed during the day in relation to pharmacokinetic data.- 8 Correlation of plasma concentrations of benzodiazepines with clinical effects.- 9 Effects of benzodiazepines on sleep and on performance: studies in healthy man.- 10 Amnesic action and residual effects of benzodiazepines used for intravenous sedation.- 11 Sleep and mood: measuring the sleep quality.- Discussion II.- Section III Treatment of Sleep Disorders 2. Clinical Experience.- 12 Comparative studies with hypnotics.- 13 Pharmacological treatment of sleep disorders.- 14 Role of the sleep laboratory in the evaluation of hypnotic drugs.- 15 A sleep laboratory in a department of psychiatry.- Discussion III.

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